模型信息
中文名称:SARS-CoV-2 nCoV-WA1-2020 气管,滴鼻,口腔,眼途径联合感染恒河猴模型
英文名称:SARS-CoV-2 nCoV-WA1-2020 intratracheally, intranasally, orally, ocularly infection rhesus macaques mouse model
类型:SARS-CoV-2感染动物模型
分级:NA
用途:用于新冠肺炎COVID-19致病机制研究、疫苗和药物评估。
研制单位:落基山实验室@@http://www.niaid.nih.gov/
保存单位:落基山实验室@@http://www.niaid.nih.gov/
研究背景
暂无介绍
制备方法
NHPs - 9 adult rhesus macaques (8M, 1F) were randomly divided into two groups of six and three animals. Group 1 was vaccinated with ChAdOx1 nCoV-19 at -28 DPI, group 2 was vaccinated with ChAdOx1 GFP at -28 DPI. All vaccinations were done with 2.5*10**10|VP/animal diluted in sterile PBS. Blood samples were obtained before vaccination and 14 days thereafter. Animals were challenged with SARS-CoV-2 strain nCoV-WA1-2020 (MN985325.1) diluted in sterile DMEM on 0 DPI; with administration of 4 mL intratracheally, 1 mL intranasally, 1 mL orally and 0.5 mL ocularly of 4*10**5 TCID50/mL virus suspension.
评价验证
暂无介绍
生物安全性
暂无介绍
讨论与结论
肺炎
了解中析
实验室仪器
合作客户
